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Phase Contrast and Differential Interference Contrast (DIC) Microscopy
06:49

Phase Contrast and Differential Interference Contrast (DIC) Microscopy

Published on: August 6, 2008

Phase-contrast digital tomosynthesis.

Jeffrey C Hammonds1, Ronald R Price, Edwin F Donnelly

  • 1Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. jeff.hammonds@vanderbilt.edu

Medical Physics
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Phase-contrast digital tomosynthesis (PC-DTS) is feasible using conventional X-ray sources. PC-DTS images retain edge enhancement and improve object contrast by reducing superimposed structures, enhancing soft-tissue visibility.

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Area of Science:

  • Medical Imaging
  • Radiography
  • Tomosynthesis

Background:

  • Phase-contrast (PC) edge enhancement is an interference effect at tissue boundaries caused by differential X-ray phase-shifts.
  • This effect is observable in planar PC radiographs.
  • The impact of digital tomosynthesis on PC edge enhancement has not been previously studied.

Purpose of the Study:

  • To demonstrate the feasibility of phase-contrast digital tomosynthesis (PC-DTS) with a conventional X-ray source.
  • To show that reconstructed tomosynthesis images retain PC edge enhancement compared to planar PC radiographs.
  • To illustrate that tomosynthesis improves object contrast by minimizing superimposed structures.

Main Methods:

  • Utilized an unmodified commercial X-ray system (Faxitron LX-60) with a tungsten anode.
  • Acquired PC radiographic images at 24 kVp and 3 mAs using a 0.010 mm focal spot.
  • Reconstructed 56 longitudinal tomographic images from planar images acquired during object rotation (+/- 25 degrees).

Main Results:

  • Achieved a tomographic z-plane resolution of approximately 4 mm.
  • Demonstrated retention of PC boundary edge enhancement in tomosynthesis images compared to planar PC images.
  • Observed an improvement in object contrast within the tomosynthesis images.

Conclusions:

  • PC digital tomosynthesis is achievable with standard X-ray equipment.
  • PC-DTS successfully retains edge enhancement seen in planar PC radiography.
  • PC-DTS enhances soft-tissue conspicuity by reducing the impact of superimposed structures.