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Related Concept Videos

Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
Brick Cutting Techniques01:08

Brick Cutting Techniques

Brick-cutting techniques involve various tools and methods to shape bricks for construction. A mason's hammer with a chisel-pointed end is used for basic shaping through sharp, precise strikes. For more complex shapes requiring higher precision, a power saw with a water-cooled diamond blade is used.
Cut bricks are categorized by size. Bricks cut to half their original length are called half-bats, while those cut to three-fourths their length are known as three-fourth bats.
Special types of cut...
The Buckingham Pi Theorem01:09

The Buckingham Pi Theorem

The Buckingham Pi theorem provides a structured method to simplify fluid dynamics problems by reducing complex systems of variables to dimensionless terms.
Heuristics01:21

Heuristics

Heuristics are problem-solving strategies that use mental shortcuts to simplify decision-making. Unlike algorithms, which must be followed precisely to achieve a correct result, heuristics offer a general problem-solving framework. They save time and energy but can sometimes lead to less rational decisions.
People often rely on heuristics when faced with an overload of information, limited time, low importance of the decision, limited information, or when a heuristic readily comes to mind. For...

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Related Experiment Video

Updated: May 30, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

The hedgehog knows many tricks.

Glen J Weiss1, Alain C Mita, Daniel D Von Hoff

  • 1Scottsdale Clinical Research Institute, Scottsdale, AZ 85238, USA. gweiss@tgen.org

Current Drug Targets
|July 23, 2011
PubMed
Summary

The Hedgehog (HH) signaling pathway surprisingly promotes cancer through multiple mechanisms. This review summarizes HH pathway functions, clinical relevance, and future therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • The Hedgehog (HH) signaling pathway plays a crucial role in embryonic development.
  • Aberrant HH pathway activation is implicated in various human cancers.
  • Understanding HH pathway's oncogenic roles is vital for cancer therapy.

Purpose of the Study:

  • To review the multifaceted roles of the Hedgehog signaling pathway in carcinogenesis.
  • To discuss the clinical relevance and current treatment strategies targeting the HH pathway.
  • To explore future therapeutic opportunities in HH pathway-driven cancers.

Main Methods:

  • Literature review of HH signaling pathway.
  • Analysis of HH pathway's involvement in cancer development.

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Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

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An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice
09:50

An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice

Published on: March 10, 2011

Related Experiment Videos

Last Updated: May 30, 2026

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents
09:01

The Double-H Maze: A Robust Behavioral Test for Learning and Memory in Rodents

Published on: July 8, 2015

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
07:26

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis

Published on: January 31, 2025

An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice
09:50

An Alternant Method to the Traditional NASA Hindlimb Unloading Model in Mice

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  • Summary of clinical applications and treatment outcomes.

    • Main Results:

    • The HH pathway contributes to cancer through at least three distinct mechanisms.
    • Clinical relevance of HH pathway dysregulation in patient populations is detailed.
    • Current treatments and future directions for HH pathway inhibition are presented.

    Conclusions:

    • The Hedgehog signaling pathway is a significant driver of carcinogenesis.
    • Targeting the HH pathway offers a promising therapeutic avenue for cancer treatment.
    • Further research into HH pathway modulation is warranted for improved patient outcomes.