Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Potential-dependent calcium channels in rabbit jejunum.

A P Sen1, S K Bhattacharya, P R Rao

  • 1Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.

Indian Journal of Experimental Biology
|October 1, 1990
PubMed
Summary

Isolated rabbit jejunum exhibits biphasic contractions, both phasic and tonic, mediated by potential-dependent calcium channels. These responses are blocked by various calcium antagonists, suggesting distinct calcium pools or channels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of genotype by environment interaction and adaptability in lowland irrigated rice hybrids for grain yield under high temperature.

Scientific reports·2021
Same author

EXTENSIVE ABDOMINAL HYDATID DISEASE.

Medical journal, Armed Forces India·2017
Same author

A Facile Synthesis, In vitro Antiinflammatory and Antioxidant activity of Novel Benzimidazolylpyrano[2,3-d][1,3]thiazolocarbonitriles.

Indian journal of pharmaceutical sciences·2015
Same author

Anxiogenic activity of intraventricularly administered bradykinin in rats.

Journal of psychopharmacology (Oxford, England)·2012
Same author

Effects of muscarinic receptor agonists and antagonists on swim-stress-induced 'behavioural despair' in rats.

Journal of psychopharmacology (Oxford, England)·2012
Same author

A rare case of antepartum posterior reversible encephalopathy syndrome.

Anaesthesia and intensive care·2011

Area of Science:

  • Pharmacology
  • Physiology
  • Gastroenterology

Background:

  • Smooth muscle contraction is regulated by calcium influx through potential-dependent calcium channels.
  • The rabbit jejunum is a model for studying gastrointestinal smooth muscle function.
  • Phasic and tonic contractions are characteristic responses in smooth muscles.

Purpose of the Study:

  • To investigate the role of potential-dependent calcium channels in rabbit jejunum contractions.
  • To characterize the biphasic contractile responses (phasic and tonic) in the isolated rabbit jejunum.
  • To determine the effects of specific calcium channel blockers on these responses.

Main Methods:

  • Isolated rabbit jejunum preparations were used.
  • Contractile responses were measured in the presence and absence of calcium antagonists.

Related Experiment Videos

  • Drugs tested included bepridil, diltiazem, nifedipine, PN 200-110 (isradipine), and verapamil.

    • Main Results:

    • A biphasic contractile response was observed: a transient, rapid contraction followed by partial relaxation and a sustained plateau contraction.
    • Both the transient (phasic) and sustained (tonic) contractions were significantly inhibited by all tested calcium antagonists.
    • The sensitivity to blockade suggests the involvement of potential-dependent calcium channels in both phases of contraction.

    Conclusions:

    • Potential-dependent calcium channels play a crucial role in mediating both phasic and tonic contractions in the rabbit jejunum.
    • The observed biphasic response suggests the existence of either two distinct calcium pools or two types of calcium channels regulating jejunal smooth muscle activity.
    • Calcium antagonists effectively block these channels, highlighting their therapeutic potential in modulating gastrointestinal motility.