Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

[Respiratory Medicine and Research: The new SPLF's anglophone journal].

Revue de pneumologie clinique·2018
Same journal

[Medical journals publication: Let's change].

Revue de pneumologie clinique·2018
Same journal

[Multiple ulcerated tracheobronchial mucosal lesions in the eosinophilic granulomatosis with polyangiitis].

Revue de pneumologie clinique·2018
Same journal

[Medium and long-term respiratory outcome in patients operated from congenital diaphragmatic hernia: From a series of 56 patients].

Revue de pneumologie clinique·2018
Same journal

[Sporadic lymphangioleiomyomatosis: A rare cause of bilateral spontaneous pneumothorax in young woman].

Revue de pneumologie clinique·2018
Same journal

[COPD and smoking cessation: Patients' expectations and responses of health professionals].

Revue de pneumologie clinique·2018
See all related articles

Related Experiment Video

Updated: May 30, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
07:59

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

[Searching for EGFR: current practices].

M-G Denis1

  • 1Laboratoire de biochimie, institut de biologie, hôpital Hôtel-Dieu, 9, quai Moncousu, 44093 Nantes cedex 01, France. marc.denis@chu-nantes.fr

Revue De Pneumologie Clinique
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Molecular biology centers reported a 13% EGFR mutation rate in early 2010. Most centers test adenocarcinomas and common EGFR mutation sites using sequencing, aiming to improve sensitivity and quality control.

More Related Videos

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

Related Experiment Videos

Last Updated: May 30, 2026

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer
07:59

Ultra-Fast Amplicon-Based Next-Generation Sequencing in Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure
09:38

Establishing Dual Resistance to EGFR-TKI and MET-TKI in Lung Adenocarcinoma Cells In Vitro with a 2-step Dose-escalation Procedure

Published on: August 11, 2017

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Epidermal Growth Factor Receptor (EGFR) mutations are key targets in non-small cell lung cancer treatment.
  • Standardized molecular testing is crucial for identifying patients eligible for targeted therapies.

Purpose of the Study:

  • To assess the landscape of EGFR mutation testing practices in molecular biology centers in early 2010.
  • To identify common mutation sites, histological types tested, and methodologies employed.

Main Methods:

  • A questionnaire was distributed to 28 molecular biology centers.
  • Data collected included mutation rates, tumor types, tested EGFR mutation sites, and methodologies.

Main Results:

  • A 13% EGFR mutation rate was observed in the first semester of 2010.
  • Adenocarcinomas constituted 87% of tested tumors, though other histological types were also analyzed.
  • Exons 19 and 21 were universally tested, with sequencing being the predominant method, albeit considered low sensitivity by many.

Conclusions:

  • Sequencing was the primary method for EGFR mutation detection, despite perceived limitations in sensitivity.
  • Centers were actively seeking to enhance techniques and implement robust quality controls for EGFR mutation testing.