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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Changes in the Appendicular Skeleton with Age01:09

Changes in the Appendicular Skeleton with Age

The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Functional Classification of Joints01:09

Functional Classification of Joints

Functional Classification of Joints
The functional classification of joints is determined by the amount of mobility between the adjacent bones. Joints are functionally classified as a synarthrosis or immobile joint, an amphiarthrosis or slightly moveable joint, or as a diarthrosis, a freely moveable joint. Fibrous and cartilaginous joints can be functionally classified as either synarthroses  or amphiarthroses, whereas all synovial joints are classified as diarthroses.
Synarthrosis
An immobile...

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Related Experiment Video

Updated: May 30, 2026

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint
06:06

Tissue Collection and RNA Extraction from the Human Osteoarthritic Knee Joint

Published on: July 22, 2021

Arthritis, occupational class, and the aging US workforce.

Alberto J Caban-Martinez1, David J Lee, Lora E Fleming

  • 1Department of Epidemiology and Public Health, University of Miami, Miller School of Medicine, FL 33136, USA. acaban@med.miami.edu

American Journal of Public Health
|July 23, 2011
PubMed
Summary

Arthritis significantly reduces quality-adjusted life years (QALYs) for blue-collar workers, impacting their ability to work longer. This highlights the need for better health and disability insurance for the aging workforce.

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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model
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Standardized Histomorphometric Evaluation of Osteoarthritis in a Surgical Mouse Model

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Area of Science:

  • Public Health
  • Gerontology
  • Health Economics

Background:

  • The working poor often delay retirement due to financial necessity.
  • Higher disease and disability risks in this population threaten financial stability and work longevity.
  • Arthritis burden by occupational class illustrates challenges for older, low-income workers.

Purpose of the Study:

  • To examine the impact of arthritis on the quality-adjusted life years (QALYs) of older workers across different occupational classes.
  • To illustrate the challenges faced by the aging poor, specifically concerning disease burden and retirement.

Main Methods:

  • Data merged from National Health Interview Survey, Medical Expenditure Panel Survey, and National Death Index.
  • Calculated and compared age- and occupational class-specific QALYs for workers with and without arthritis.
  • Utilized unabridged life tables for analysis.

Main Results:

  • White-collar workers report higher overall health-related quality of life and fewer QALYs lost to arthritis.
  • A 65-year-old white-collar worker without arthritis has 17 QALYs, compared to 11 QALYs for a blue-collar worker with arthritis.
  • Blue-collar workers with arthritis are less likely to remain in the workforce.

Conclusions:

  • The aging workforce, particularly those in physically demanding jobs, faces significant health and financial challenges.
  • Current health and disability insurance may be insufficient to meet the needs of older, vulnerable workers.
  • Policy interventions focusing on enhanced health and disability insurance are crucial for the aging workforce.