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Chronic Obstructive Pulmonary Disease I: Introduction

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Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...

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Chronic Obstructive Pulmonary Disease

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Related Experiment Video

Updated: May 30, 2026

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure

Published on: August 25, 2017

Genetics of COPD.

Hidetoshi Nakamura¹

¹Department of Medicine, Tokyo Electric Power Company Hospital, Japan. htnakam@nifty.com

Allergology International : Official Journal of the Japanese Society of Allergology

|July 23, 2011

Summary

This summary is machine-generated.

Genetic variations influence Chronic Obstructive Pulmonary Disease (COPD) susceptibility. Genome-wide association studies identified several genes, including CHRNA3/5, HHIP, and FAM13A, linked to COPD risk and pathogenesis.

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Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function

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Area of Science:

Genetics
Pulmonology
Epidemiology

Background:

Genetic factors are implicated in Chronic Obstructive Pulmonary Disease (COPD) susceptibility.
SERPINA1 (α1-antitrypsin) is the only gene definitively linked to COPD risk.
Previous studies showed inconsistent replication for many candidate genes.

Purpose of the Study:

To review and synthesize findings from genetic studies investigating COPD susceptibility.
To highlight genes and loci associated with COPD risk identified through various genetic approaches.

Main Methods:

Review of family studies, candidate gene studies, meta-analyses, family-based linkage analyses.
Analysis of genome-wide association (GWA) studies.

Main Results:

SERPINA1 is a key gene influencing COPD susceptibility.
Variants in EPHX1, GST, MMP12, TGFB1, and SERPINE2 are suggested to be associated with COPD.
GWA studies identified CHRNA3/5, HHIP, FAM13A, and BICD1 loci associated with COPD, emphysema, or related traits like nicotine dependence.

Conclusions:

Genetic studies, despite limitations like heterogeneity, have advanced understanding of COPD pathogenesis.
Future research aims to elucidate mechanisms of this polygenic disease for targeted therapies.