Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemistry of the Cell02:58

Chemistry of the Cell

The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity and heat of...
Chemistry of the Cell02:58

Chemistry of the Cell

The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity and heat of...
Cell-surface Signaling01:21

Cell-surface Signaling

Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
Introduction to Membrane Traffic01:44

Introduction to Membrane Traffic

The ER, Golgi apparatus, endosomes, and lysosomes work in tandem to modify, sort, and package proteins and lipids. An integrated membrane trafficking network facilitates the back and forth shuttling of molecules within different organelles in the same cell or across the cell membrane.
The transport of soluble and membrane proteins is mediated by transport vesicles that collect cargo from one cellular compartment and deliver it to another by fusing with the target organelle membrane. The Rab...
Cellular Membranes and Drug Transport01:24

Cellular Membranes and Drug Transport

Drugs must traverse multiple biological barriers, such as multi-layered skin, single-layered intestinal epithelium, and the plasma membrane, to reach their target sites within the body. The plasma membrane, a highly structured composite of phospholipids, carbohydrates, and proteins, is the cell's protective boundary, facilitating selective substance exchange.
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
Enlargement of the Plasma Membrane01:22

Enlargement of the Plasma Membrane

Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Dural Extracellular Matrix Hydrogel with Neural Stem Cells Improves Recovery from Traumatic Brain Injury in Mice.

ACS biomaterials science & engineering·2026
Same author

BODIPY Photocage-Based Injectable Hydrogel for Light-Controlled Nanoparticle Release.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Bionano Interface Optimization for Rational Lateral Flow Assay Development.

ACS nano·2026
Same author

Image-guided optimization of regenerative graft attachment to the heart.

Biomaterials·2026
Same author

Towards intelligent and miniaturized drug delivery devices.

Nature·2026
Same author

The Impact of Polyethylene Glycol Lipid Anchors on the Physicochemical Properties, Protein Corona, Function, and Biodistribution of Lipid Nanoparticles.

ACS nano·2026

Related Experiment Video

Updated: May 30, 2026

Glycopeptide Capture for Cell Surface Proteomics
10:11

Glycopeptide Capture for Cell Surface Proteomics

Published on: May 9, 2014

Exploring and exploiting chemistry at the cell surface.

Morgan D Mager1, Vanessa LaPointe, Molly M Stevens

  • 1Royal School of Mines, Prince Consort Road, Imperial College, London SW7 2AZ.

Nature Chemistry
|July 23, 2011
PubMed
Summary
This summary is machine-generated.

Chemists are engineering bioactive interfaces by synthesizing materials that mimic complex cell surfaces. This research explores functional molecules and dynamic surfaces for advanced cell-material interactions.

More Related Videos

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome
06:31

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome

Published on: March 24, 2023

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells
04:55

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Published on: February 23, 2011

Related Experiment Videos

Last Updated: May 30, 2026

Glycopeptide Capture for Cell Surface Proteomics
10:11

Glycopeptide Capture for Cell Surface Proteomics

Published on: May 9, 2014

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome
06:31

"Cell Surface Capture" Workflow for Label-Free Quantification of the Cell Surface Proteome

Published on: March 24, 2023

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells
04:55

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Published on: February 23, 2011

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Cell Biology

Background:

  • Cell surfaces exhibit intricate, dynamic arrangements of lipids, proteins, and carbohydrates.
  • This complexity poses significant challenges for creating effective bioactive interfaces.

Purpose of the Study:

  • To discuss strategies for engineering material surfaces to interface with complex cell structures.
  • To review common functional molecules used in surface modification.
  • To explore novel approaches for dynamic, responsive biomaterials.

Main Methods:

  • Interdisciplinary material synthesis.
  • Grafting of functional molecules onto engineered surfaces.
  • Development of dynamic surface technologies.

Main Results:

  • Successful strategies for creating bioactive interfaces using advanced material synthesis.
  • Identification of popular and alternative functional molecules for surface modification.
  • Advancements in dynamic surfaces that interact with cellular activity.

Conclusions:

  • Interdisciplinary approaches are crucial for overcoming the challenges of cell-surface engineering.
  • Functional molecules and dynamic surfaces offer enhanced specificity and real-time cellular interaction.
  • The field of dynamic bioactive interfaces holds significant promise for future applications.