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Interleukin-6 (-636 c/g) gene polymorphism in korean children with kawasaki disease

Hye Mi Ahn1, In Sook Park, Soo-Jong Hong

  • 1Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul, Korea.

Korean Circulation Journal
|July 23, 2011
PubMed

Insights

This study found no link between the IL-6 (-636 C/G) gene polymorphism and Kawasaki disease (KD) or its coronary artery lesions. Higher serum IL-6 levels were observed in KD patients with specific genotypes.

Area of Science:

  • Pediatric Rheumatology
  • Immunogenetics
  • Cardiovascular Research

Background:

  • Kawasaki disease (KD) is a vasculitis affecting children, with potential coronary artery complications.
  • Elevated serum interleukin-6 (IL-6) levels correlate with fever duration in untreated KD.
  • The role of IL-6 gene polymorphism in KD development remains debated.

Purpose of the Study:

  • To investigate the association between the IL-6 (-636 C/G) gene polymorphism and Kawasaki disease.
  • To examine the relationship between this polymorphism and coronary arterial lesions in KD patients.
  • To compare serum IL-6 levels in KD patients with controls and correlate them with genotypes.

Main Methods:

  • Case-control study comparing 109 KD patients with 191 children with congenital heart disease.
  • Echocardiography to assess cardiac involvement in KD.
  • Genotyping of IL-6 (-636 C/G) polymorphism and serum IL-6 concentration measurement.

Main Results:

  • KD patients exhibited significant differences in neutrophil, platelet, liver function, total protein, and albumin levels compared to controls.
  • Serum IL-6 concentrations were significantly higher in KD patients, particularly those with -636 C/G or GG genotypes.
  • No association was found between IL-6 (-636 C/G) polymorphism and coronary arterial dilatation in KD.

Conclusions:

  • The IL-6 (-636 C/G) gene polymorphism is not associated with the development of coronary arterial lesions in Kawasaki disease.
  • Further multicenter research is needed to clarify the relationship between IL-6 gene polymorphism and KD susceptibility.
  • Elevated serum IL-6 in KD patients may be linked to specific genotypes, warranting further investigation.
Abstract

Keywords:
InterleukinsMucocutaneous lymph node syndromePolymorphism, genetic

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