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Related Experiment Video

Updated: May 30, 2026

Identification and Dissection of Diverse Mouse Adipose Depots

Identification and Dissection of Diverse Mouse Adipose Depots

Published on: July 11, 2019

Adipose tissue mass and location affect circulating adiponectin levels.

A T Turer¹, A Khera, C R Ayers

¹Department of Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-8521, USA. Aslan.Turer@UTSouthwestern.edu

|July 23, 2011

Summary

Adipose tissue distribution, not just overall body mass, influences adiponectin levels. Lower extremity fat is linked to higher adiponectin, while truncal fat is linked to lower levels, irrespective of ethnicity or sex.

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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

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Published on: July 17, 2018

Area of Science:

Endocrinology
Body Composition Analysis
Metabolic Health

Background:

Plasma adiponectin levels are known to correlate inversely with body mass.
The influence of adipose tissue distribution on adiponectin concentrations requires further investigation.

Purpose of the Study:

To investigate the hypothesis that adipose tissue distribution and body composition significantly influence plasma adiponectin levels.

Main Methods:

Assessed plasma adiponectin concentrations in 2,820 participants from the Dallas Heart Study.
Utilized dual-energy X-ray absorptiometry (DEXA) to measure body composition.
Analyzed associations between adiponectin levels, body fat distribution (lower extremity vs. truncal), and ethnicity.

Main Results:

Adiponectin levels were higher in White individuals compared to Hispanic and African American individuals across sexes.
Multivariate analysis revealed a positive association between lower extremity fat (absolute and relative) and adiponectin levels.
Conversely, adiponectin levels were negatively correlated with truncal fat (absolute and relative) across ethnicities and sexes.

Conclusions:

Adipose tissue depot location differentially impacts circulating adiponectin concentrations, independent of ethnicity and sex.
Overall body mass is insufficient to fully explain adiponectin levels.
Adiponectin may mediate the beneficial effects of lower extremity adiposity on insulin sensitivity.