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Published on: February 3, 2013
Epigenetic features that regulate IgH locus recombination and expression
Ramesh Subrahmanyam1, Ranjan Sen
1National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
Abstract:
Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D (H) gene segment to a J (H) gene segment to generate DJ(H) junctions, followed by rearrangement of a V (H) gene segment to the DJ(H) junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.
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