Hypercalcaemia, hyperphosphataemia and cytoplasmic inclusions in a patient with chronic lymphocytic leukaemia

The history of a patient with chronic lymphocytic leukaemia (CLL), known for ten years, is presented. During the terminal stage of the disease, she developed hypercalcaemia and hyperphosphataemia. The peripheral blood and lymph node lymphocytes contained crystalline inclusions in the dilated cisterns of the endoplasmic reticulum. The possible mechanism of hypercalcaemia and hyperphosphataemia and the significance of the crystalline inclusion are discussed.