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Updated: May 30, 2026
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Split-and-pool Synthesis and Characterization of Peptide Tertiary Amide Library
Published on: June 20, 2014
Pyrrolinone-pyrrolidine oligomers as universal peptidomimetics
Arjun Raghuraman1, Eunhwa Ko, Lisa M Perez
1Department of Chemistry and Laboratory for Molecular Simulation, Texas A&M University, Box 30012, College Station, Texas 77842, United States.
Journal of the American Chemical Society
|July 26, 2011
Abstract:
Peptidomimetics 1-3 were prepared from amino acid-derived tetramic acids 7 as the key starting materials. Calculations show that preferred conformations of 1 can align their side-chain vectors with amino acids in common secondary structures more effectively than conformations of 3. A good fit was found for a preferred conformation of 2 (an extended derivative of 1) with a sheet/β-turn/sheet motif.
