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Updated: May 30, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
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Conjugate addition-initiated Nazarov cyclization

Joshua L Brooks1, Patrick A Caruana, Alison J Frontier

  • 1Department of Chemistry, University of Rochester, Rochester, New York 14627, United States.

Journal of the American Chemical Society
|July 26, 2011
PubMed
Summary

This study details a reaction sequence starting with nucleophile addition to a dienyl diketone, followed by Nazarov cyclization. Different outcomes arise based on nucleophile quantity, impacting the reaction pathway.

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