Related Experiment Videos
Binding of zinc and cadmium to human serum albumin
S T Trisak1, P Doumgdee, B M Rode
1Institut für Anorganische und Analytische Chemie, Universität Innsbruck, Osterreich.
The International Journal of Biochemistry
|January 1, 1990
Abstract:
1. The interaction of zinc and cadmium ion with human serum albumin (HSA) is evaluated and compared by potentiometric titration method and computer simulation of complex equilibria. 2. Zinc binds to histidine and free amino groups, cadmium in addition to basic functional groups of the protein. 3. Whereas zinc binds stronger in 1:1 complexes, chelate binding favours cadmium ions. 4. Within biological pH-conditions, high amounts Zn(II) and even more of Cd(II) will be bound to HSA.