Related Experiment Video
Updated: May 30, 2026

Assembly of Cell Mimicking Supported and Suspended Lipid Bilayer Models for the Study of Molecular Interactions
Published on: August 3, 2021
Polymer membrane and cell models for drug discovery
Chong Shen1, Liang Zhang, Guoliang Zhang
1College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou, P.R. China. mengq@zju.edu.cn
Abstract:
This paper reviews the functional polymer membrane and membrane based cell drug evaluation models for drug discovery. Based on the characteristics of biological membranes in vivo, chemical modification methods of synthetic membrane, including blending and surface modification are explored to mitigate the membrane fouling and improve biocompatibility. Different membrane-based cell models used in drug investigation and related trouble shooting are analyzed in detail. Specific attention is given to the current studies on ADME/Tox of drugs using membrane-based in vitro models of cells including Caco-2, hepatocytes or renal cells, which can be used to evaluate the feasibility of polymer membrane in drug investigation. The progress toward solving present bottlenecks of the facilitated cell models are supposed to provide great benefits to drug discovery in pharmaceutical industry.
Related Concept Videos
Cellular Membranes and Drug Transport
Phospholipids arrange themselves into a bilayer, with hydrophilic heads oriented outward and hydrophobic tails facing inward.
The Fluid Mosaic Model
Fluid Mosaic Model
Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
In Vitro Drug Dissolution: Compendial Testing Models II

