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Synovial fluid D-dimer concentration in foals with septic joint disease
T Ribera1, L Monreal, L Armengou
1Servei de Cirurgia Equina, Universitat Autònoma de Barcelona, Barcelona, Spain. thais.ribera@uab.cat
Journal of Veterinary Internal Medicine
|July 26, 2011
Summary
Septic joint disease in foals significantly increases synovial D-Dimer concentrations, indicating heightened fibrinolytic activity. This finding suggests D-Dimer may serve as a valuable diagnostic marker for joint sepsis in foals.
Area of Science:
- Veterinary Medicine
- Equine Health
- Biochemistry
Background:
- Increased synovial fibrinolytic activity, evidenced by elevated synovial D-Dimer, is recognized in various joint diseases.
- This activity is presumed to mitigate harmful fibrin deposition within joints.
Purpose of the Study:
- To evaluate fibrinolytic pathway activation in foals with joint sepsis.
- To measure synovial D-Dimer concentrations in septic foals.
Main Methods:
- A prospective observational clinical study involved 18 septic foals with septic joints, 9 septic foals without joint disease, 9 healthy foals with septic joints, and 3 controls.
- Synovial fluid was analyzed for D-Dimer concentration and routine parameters.
- Joint sepsis was diagnosed based on specific cell counts, protein levels, neutrophil percentages, or positive synovial fluid culture.
Main Results:
- Synovial D-Dimer concentration was significantly higher in foals with septic joints compared to those without joint disease (P < .001).
Conclusions:
- Septic joint disease in foals is linked to a substantial increase in synovial D-Dimer concentration, reflecting marked fibrinolytic activity.
- Synovial D-Dimer measurement could be a useful complementary diagnostic marker for septic joint disease in foals, warranting further investigation.
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