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07:07
Quantification of the Respiratory Burst Response as an Indicator of Innate Immune Health in Zebrafish
Published on: September 12, 2013
Innate immunity and coagulation.
Journal of Thrombosis and Haemostasis : JTH
|July 26, 2011
Summary
Infection triggers blood clotting (coagulation) by activating tissue factor and inhibiting natural anticoagulants. This response, while aiding pathogen clearance, can paradoxically cause tissue damage and organ failure.
Area of Science:
- Coagulation and Inflammation Biology
- Infectious Disease Pathophysiology
Background:
- Infection often triggers a pro-coagulant state.
- Endotoxin initiates coagulation via tissue factor.
- Anticoagulant pathways and fibrinolysis are suppressed during infection.
Purpose of the Study:
- To elucidate the complex interplay between infection, coagulation, and tissue injury.
- To understand how coagulation contributes to both host defense and organ failure.
Main Methods:
- Review of the physiological mechanisms linking infection to coagulation.
- Analysis of the role of endotoxin and cellular components in the response.
Main Results:
- Infection promotes coagulation by enhancing initiation, downregulating anticoagulation (e.g., protein C pathway), and inhibiting fibrin removal.
- Tissue destruction releases nucleosomes and histones, exacerbating inflammation and injury.
- This complex response aims to control and clear infectious agents.
Conclusions:
- The coagulation system plays a dual role in infection, facilitating pathogen clearance while potentially causing significant host tissue damage.
- Dysregulation of coagulation during infection contributes to multi-organ failure.
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