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Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
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Exploration of the host haemostatic system by group A streptococcus: implications in searching for novel

H Sun1

  • 1Department of Internal Medicine, University of Missouri Hospital and Clinics, Columbia, MO, USA. sunh@health.missouri.edu

Journal of Thrombosis and Haemostasis : JTH
|July 26, 2011
PubMed

The haemostatic system is heavily involved in the host response to infection. A number of host haemostatic factors, notably plasminogen and fibrinogen have been reported to bind and interact with various bacterial proteins. This review summarises the roles of host haemostatic factors such as plasminogen, factor V and fibrinogen in host defence against group A streptococcus infection and discusses the potential of targeting the host haemostatic system for therapeutic intervention against infectious diseases.

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