Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Venous Thrombosis I: Introduction01:30

Venous Thrombosis I: Introduction

Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies01:20

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...
Venous Thrombosis IV: Nursing Management01:30

Venous Thrombosis IV: Nursing Management

Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minor allele of the factor V K858R variant protects from venous thrombosis only in non-carriers of factor V Leiden mutation.

Scientific reports·2019
Same author

The missing heritability of venous thrombosis: what about factor V Leiden heterogeneity?

Journal of thrombosis and haemostasis : JTH·2018
Same author

Peripartum bleeding management in a patient with CalDAG-GEFI deficiency.

Haemophilia : the official journal of the World Federation of Hemophilia·2017
Same author

Protein S Heerlen mutation heterozygosity is associated with venous thrombosis risk.

Scientific reports·2017
Same author

α<sub>1</sub> -antitrypsin Pittsburgh and plasmin-mediated proteolysis.

Journal of thrombosis and haemostasis : JTH·2016
Same author

Is there still room for additional common susceptibility alleles for venous thromboembolism?

Journal of thrombosis and haemostasis : JTH·2016

Related Experiment Video

Updated: May 30, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Lessons from genome-wide association studies in venous thrombosis.

P E Morange1, D A Tregouet

  • 1INSERM, UMR_S 626, Marseille, France. pierre.morange@ap-hm.fr

Journal of Thrombosis and Haemostasis : JTH
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

Genome-Wide Association Studies (GWAS) have identified numerous genetic factors for complex diseases. This review highlights the significant impact of GWAS on advancing venous thrombosis genetics research.

More Related Videos

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
04:34

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis

Published on: June 15, 2011

Related Experiment Videos

Last Updated: May 30, 2026

Venous Thrombosis Assay in a Mouse Model of Cancer
04:40

Venous Thrombosis Assay in a Mouse Model of Cancer

Published on: January 5, 2024

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis
04:34

Mouse Complete Stasis Model of Inferior Vena Cava Thrombosis

Published on: June 15, 2011

Area of Science:

  • Genetics
  • Genomics
  • Molecular Biology

Background:

  • Genome-Wide Association Studies (GWAS) have revolutionized human genetics research since 2005.
  • Hundreds of studies have utilized GWAS to identify genetic loci for various diseases and risk factors.
  • The field is transitioning towards next-generation sequencing technologies.

Purpose of the Study:

  • To illustrate the benefits and contributions of the GWAS paradigm to genetic research in venous thrombosis.
  • To provide an overview of how GWAS has advanced the understanding of venous thrombosis genetics.

Main Methods:

  • Review of published Genome-Wide Association Studies relevant to venous thrombosis.
  • Analysis of genetic loci identified through GWAS for venous thrombosis.
  • Synthesis of findings from multiple GWAS in the context of venous thrombosis etiology.

Main Results:

  • GWAS have successfully identified multiple genetic risk factors for venous thrombosis.
  • These studies have elucidated the genetic architecture underlying venous thrombosis.
  • The application of GWAS has significantly expanded the knowledge of venous thrombosis pathogenesis.

Conclusions:

  • The GWAS paradigm has been instrumental in advancing the genetic understanding of venous thrombosis.
  • Continued application and integration with new technologies will further unravel the genetic basis of venous thrombosis.
  • Genetic insights from GWAS contribute to understanding disease mechanisms and potential therapeutic targets.