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[Relationship between fractional esterification rate of high density lipoprotein cholesterol and coronary artery

Wen Mao1, Jun Dong, Hong-xia Li

  • 1Department of Cardiology, Beijing Hospital, Beijing 100730, China.

Zhonghua Xin Xue Guan Bing Za Zhi
|July 26, 2011
PubMed

Insights

Fractional esterification rate of high density lipoprotein cholesterol (FER(HDL)) is elevated in patients with coronary artery disease (CAD). Higher FER(HDL) levels correlate with increased CAD severity, indicating its potential as a biomarker.

Area of Science:

  • Cardiovascular Medicine
  • Clinical Biochemistry
  • Lipid Metabolism

Background:

  • Coronary artery disease (CAD) remains a leading cause of mortality worldwide.
  • Understanding novel biomarkers for CAD risk stratification is crucial.
  • High-density lipoprotein cholesterol (HDL-C) plays a protective role, but its functional aspects are less understood.

Purpose of the Study:

  • To investigate the association between the fractional esterification rate of HDL cholesterol (FER(HDL)) and the presence and severity of CAD.
  • To determine if FER(HDL) can serve as a potential biomarker for CAD.

Main Methods:

  • A cohort of 131 patients undergoing coronary angiography for chest pain was studied.
  • Patients were categorized into CAD (n=76) and non-CAD (n=55) groups.
  • Clinical data, biochemical parameters, FER(HDL), and lipid subclasses were analyzed.

Main Results:

  • FER(HDL) levels were significantly higher in the CAD group compared to the non-CAD group (21.70 ± 8.73 vs. 18.65 ± 6.26, P < 0.05).
  • A positive correlation was observed between FER(HDL) and the number of diseased coronary arteries, with a significant difference between non-CAD and 3-vessel disease groups (18.65 ± 6.26 vs. 24.00 ± 9.22, P < 0.05).
  • FER(HDL) showed positive correlations with triglycerides (TG) and LDLb-C, and negative correlations with HDL-C and HDL(2)-C.

Conclusions:

  • Elevated FER(HDL) values are significantly associated with the presence of CAD.
  • The study demonstrates that FER(HDL) levels correlate with the severity of coronary artery disease.
  • FER(HDL) emerges as a promising functional biomarker for assessing CAD risk and progression.
Abstract

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