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Published on: February 27, 2026
[Primary lung paraganglioma. A case report]
R Kaplan1, A Burgos, N Rodriguez
1Servicio de Patología Hospital Municipal De Urgencias Córdoba, Argentina.
Summary
Primary lung paragangliomas are rare neuroendocrine tumors. Surgical treatment is mandatory due to potential high blood pressure and malignization risks.
Area of Science:
- Pathology
- Oncology
- Endocrinology
Background:
- Primary lung paragangliomas are rare, accounting for 1-2% of all paragangliomas.
- Typically observed in individuals aged 43-61 years.
- These tumors often present as asymptomatic solitary masses.
Observation:
- Histologically, they exhibit a characteristic nesting pattern (Zellballen).
- Chief cells display uniform nuclei, granular eosinophilic cytoplasm, and positive neuroendocrine markers (Neuron Specific Enolase, synaptophysin, chromogranin A).
- Sustentacular cells are positive for S-100 protein and neurofibrillary protein.
Findings:
- Distinguishing lung paragangliomas from carcinoid tumors can be diagnostically challenging.
- The primary cells are positive for Neuron Specific Enolase, synaptophysin, and chromogranin A.
- Sustentacular cells express S-100 protein and neurofibrillary protein.
Implications:
- Surgical intervention is the recommended treatment for primary lung paragangliomas.
- Early diagnosis and treatment are crucial to manage potential complications like hypertension.
- Understanding the histological and immunohistochemical features is vital for accurate diagnosis and to assess malignization potential.
