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Related Experiment Video

Updated: May 30, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
11:17

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

[Primary lung paraganglioma. A case report].

R Kaplan1, A Burgos, N Rodriguez

  • 1Servicio de Patología Hospital Municipal De Urgencias Córdoba, Argentina.

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|July 26, 2011
PubMed
Summary

Primary lung paragangliomas are rare neuroendocrine tumors. Surgical treatment is mandatory due to potential high blood pressure and malignization risks.

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Area of Science:

  • Pathology
  • Oncology
  • Endocrinology

Background:

  • Primary lung paragangliomas are rare, accounting for 1-2% of all paragangliomas.
  • Typically observed in individuals aged 43-61 years.
  • These tumors often present as asymptomatic solitary masses.

Observation:

  • Histologically, they exhibit a characteristic nesting pattern (Zellballen).
  • Chief cells display uniform nuclei, granular eosinophilic cytoplasm, and positive neuroendocrine markers (Neuron Specific Enolase, synaptophysin, chromogranin A).
  • Sustentacular cells are positive for S-100 protein and neurofibrillary protein.

Findings:

  • Distinguishing lung paragangliomas from carcinoid tumors can be diagnostically challenging.
  • The primary cells are positive for Neuron Specific Enolase, synaptophysin, and chromogranin A.

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Last Updated: May 30, 2026

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer
11:17

Thoracoscopic Extended Right Middle Plus Lower Sleeve Lobectomy for Non-Small-Cell Lung Cancer

Published on: February 27, 2026

  • Sustentacular cells express S-100 protein and neurofibrillary protein.

    • Implications:

    • Surgical intervention is the recommended treatment for primary lung paragangliomas.
    • Early diagnosis and treatment are crucial to manage potential complications like hypertension.
    • Understanding the histological and immunohistochemical features is vital for accurate diagnosis and to assess malignization potential.