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Updated: May 30, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Food induced skin diseases.

C Bruijnzeel-Koomen¹

¹Department of Dermatology, University Hospital Utrecht, Heidelberglaan 100, NL-3584 ZS Utrecht, The Netherlands.

Environmental Toxicology and Pharmacology

|July 26, 2011

Summary

This summary is machine-generated.

Adverse food reactions can cause skin conditions like urticaria and atopic dermatitis, particularly in children. While IgE antibodies are involved, how food allergens reach the skin remains unclear.

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Area of Science:

Dermatology
Allergology
Immunology

Background:

Adverse food reactions manifest as various skin diseases, including urticaria, atopic dermatitis, and oral allergy syndrome.
Food allergens are frequently implicated in acute urticaria, while their influence on chronic urticaria is less pronounced.
The link between food and atopic dermatitis is significant in pediatric populations but less so in adults.

Purpose of the Study:

To review the relationship between food and common skin diseases.
To discuss the immunological mechanisms underlying food-induced skin conditions.
To highlight current knowledge gaps regarding allergen entry into the skin.

Main Methods:

Literature review focusing on food-induced skin diseases.
Discussion of immunological pathways, including IgE-mediated and non-immune mechanisms.
Exploration of the role of T lymphocytes and potential cutaneous homing factors.

Main Results:

Urticaria, atopic dermatitis, and oral allergy syndrome are discussed as key food-related skin conditions.
Food is a more common trigger for acute than chronic urticaria.
Food significantly impacts atopic dermatitis in children, but less so in adults.
Immune mechanisms like IgE antibodies and T lymphocytes are implicated in food-induced atopic dermatitis and some urticarial reactions.

Conclusions:

Food adverse reactions are significant causes of skin diseases like urticaria and atopic dermatitis.
The specific mechanisms of food allergen penetration into the skin are not fully understood.
Further research is needed to elucidate the role of factors like cutaneous T cell homing in these conditions.