Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Infection01:20

Infection

When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Drug Toxicity: Overview01:00

Drug Toxicity: Overview

Drug toxicity quantifies the harm a compound causes to an organism, varying by dose and potentially impacting whole systems or specific organs like the liver. Toxic reactions may arise from venomous insect or spider bites, with effects ranging from mild symptoms to severe outcomes such as brain damage or death. Common forms of acute poisoning include ethanol intoxication and overdose of pain or fever medications, with substances like GHB and heroin being particularly lethal at doses close to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of an rK39-based immunochromatographic test for the diagnosis of visceral leishmaniasis in human saliva.

Tropical biomedicine·2015
Same author

Particulate Matter and Cardiopulmonary Health: A Perspective.

Inhalation toxicology·2015
Same author

Cardiac and Thermoregulatory Toxicity of Residual Oil Fly Ash in Cardiopulmonary-Compromised Rats.

Inhalation toxicology·2015
Same author

Modulation of immune response by RAGE and TLR4 signalling in PBMCs of diabetic and non-diabetic patients.

Scandinavian journal of immunology·2014
Same author

Identification of Leishmania infantum chagasi proteins in urine of patients with visceral leishmaniasis: a promising antigen discovery approach of vaccine candidates.

Parasite immunology·2012
Same author

Ambient particulate matter and respiratory and cardiovascular illness in adults: particle-borne transition metals and the heart-lung axis(,).

Environmental toxicology and pharmacology·2011
Same journal

Metabolic perturbations underlying the associations of non-persistent organic pollutant mixtures with blood pressure: a panel study in adults.

Environmental toxicology and pharmacology·2026
Same journal

Arsenic Exposure Disrupts Human Hematopoiesis by Impairing the Generation and Function of Hematopoietic Stem and Progenitor Cells.

Environmental toxicology and pharmacology·2026
Same journal

Effects of beta-cypermethrin on the antioxidant system and gut microbiota in Eisenia fetida.

Environmental toxicology and pharmacology·2026
Same journal

Urban particulate matter impairs human epidermal keratinocyte biology via the TRPV1-mitochondrial axis and TRPV1-Notch signaling.

Environmental toxicology and pharmacology·2026
Same journal

Chlorocholine chloride disrupts differentiation of rat stem/progenitor Leydig cells: A combined in vivo and in vitro study by Leydig cell regeneration model.

Environmental toxicology and pharmacology·2026
Same journal

Teratogenic effects of imidacloprid exposure on neurogenesis and neural tube development in early stage chicken embryos.

Environmental toxicology and pharmacology·2026
See all related articles

Related Experiment Video

Updated: May 30, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Susceptibility and risk: an overview.

H Zenick1, D L Costa

  • 1National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA.

Environmental Toxicology and Pharmacology
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

Understanding individual susceptibility is crucial for accurate risk assessment. This symposium explored how environmental, genetic, and social factors influence susceptibility, aiming to improve risk management and avoidance strategies.

More Related Videos

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Related Experiment Videos

Last Updated: May 30, 2026

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans
08:21

Intradermal Microdialysis: An Approach to Investigating Novel Mechanisms of Microvascular Dysfunction in Humans

Published on: July 21, 2023

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

Area of Science:

  • Environmental Health
  • Toxicology
  • Risk Assessment

Background:

  • Susceptibility to risk is influenced by a complex interplay of environmental, genetic, social, and political factors.
  • Accurate assessment of these susceptibility factors is critical for effective risk management, including prevention, reduction, and avoidance.
  • Existing methods for incorporating susceptibility into risk assessments, such as uncertainty factors, require re-evaluation due to challenges in their scientific basis.

Purpose of the Study:

  • To explore contemporary issues in risk assessment, focusing on the multifaceted nature of susceptibility.
  • To gain a deeper understanding of the various dimensions contributing to individual and population susceptibility.
  • To identify future directions for the risk assessment process to better quantify susceptibility's role in risk calculations.

Main Methods:

  • The study is based on a symposium that convened experts from diverse scientific disciplines.
  • Discussions focused on contemporary challenges and contemporary issues in risk assessment.
  • The symposium aimed to re-examine and update current approaches to accounting for susceptibility in risk assessments.

Main Results:

  • The symposium highlighted the complexity of susceptibility, influenced by numerous interacting factors.
  • It underscored the significant implications of delineating susceptibility factors for risk management strategies.
  • Challenges to the scientific basis of current susceptibility assessment methods were identified, necessitating updates.

Conclusions:

  • A comprehensive understanding of susceptibility dimensions is essential for advancing risk assessment.
  • Improved quantification of susceptibility is needed to enhance the scientific foundation of risk calculations.
  • Future risk assessment processes should better integrate diverse susceptibility factors for more robust outcomes.