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Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

Mouse Models of Cancer Study

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Updated: May 30, 2026

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer

Published on: May 18, 2020

Mouse models for breast cancer susceptibility.

L M Bennett¹, R W Wiseman

¹Laboratory of Molecular Carcinogenesis, Mail Drop C4-06, National Institute of Environmental Health Sciences, 111 Alexander Drive, Research Triangle Park NC 27709, USA.

Environmental Toxicology and Pharmacology

|July 26, 2011

Summary

Genetic defects in p53, BRCA1, BRCA2, and ATM genes significantly increase breast cancer risk. Mice with targeted gene defects serve as crucial models for studying breast cancer susceptibility and carcinogenesis.

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Area of Science:

Oncology
Genetics
Carcinogenesis

Background:

Breast cancer is a leading malignancy in American women.
Family history is a significant risk factor, second only to age.
Key genes (p53, BRCA1, BRCA2, ATM) linked to hereditary breast cancer risk have been identified.

Purpose of the Study:

To review the current status of genetically engineered mouse models for breast cancer susceptibility.
To explore the utility of these mouse models in understanding breast carcinogenesis.
To suggest future research directions in the field.

Main Methods:

Utilizing gene targeting techniques to create mice with specific genetic defects.
Analyzing the phenotype and susceptibility of these genetically modified mice.
Reviewing existing literature on these models and their relevance to human breast cancer.

Main Results:

Genetically engineered mice with defects in p53, BRCA1, BRCA2, and ATM exhibit altered breast cancer susceptibility.
These mouse models recapitulate aspects of human hereditary breast cancer.
The models provide valuable insights into the mechanisms of breast carcinogenesis.

Conclusions:

Genetically modified mice are essential tools for investigating breast cancer etiology.
Further research using these models can enhance our understanding of breast cancer development.
These models hold promise for identifying novel therapeutic targets and prevention strategies.