Related Experiment Video
Updated: May 30, 2026
09:23
Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
Toxicant exposure and trace element metabolism in pregnancy
C L Keen1, M W Taubeneck, S Zidenberg-Cherr
1Department of Nutrition, University of California, Davis, Davis, CA 95616, USA.
Environmental Toxicology and Pharmacology
|July 26, 2011
Summary
Maternal nutrition significantly impacts fetal development. Poor diets risk pregnancy outcomes, while supplements improve them, suggesting diet modulates developmental toxicity.
Area of Science:
- Reproductive biology
- Developmental toxicology
- Nutritional science
Background:
- Maternal nutritional status critically influences embryonic and fetal development.
- Poor maternal diets are linked to adverse pregnancy outcomes, whereas nutritional supplements can improve outcomes.
- Identifying specific nutrient deficiencies causing abnormal development is challenging due to multiple deficiency mechanisms.
Purpose of the Study:
- To review the literature on maternal nutrition and embryonic/fetal development.
- To explore the hypothesis that teratogen-induced developmental toxicity involves altered trace element partitioning.
- To investigate the role of maternal diet in modulating developmental toxicity.
Main Methods:
- Literature review of studies on maternal nutrition, pregnancy outcomes, and developmental toxicity.
- Analysis of evidence supporting the trace element partitioning hypothesis.
- Examination of the interplay between maternal diet, teratogens, and fetal development.
Main Results:
- Maternal nutrition is a key factor in healthy embryonic and fetal development.
- Nutritional supplements during pregnancy are associated with improved outcomes.
- Teratogen-induced developmental toxicity may be partly explained by altered essential trace element distribution between mother and fetus.
- Maternal diet can significantly modify the developmental toxicity of certain agents.
Conclusions:
- Maternal diet plays a crucial role in modulating developmental toxicity.
- Altered essential trace element partitioning is a potential mechanism linking teratogens to developmental abnormalities.
- Optimizing maternal nutrition is vital for mitigating risks associated with environmental teratogens.
More Related Videos
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
08:46Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
Published on: April 21, 2022
Related Concept Videos
01:24Drug Toxicity: Dose-Dependent Reactions
Drug toxicities can be stratified into pharmacological, pathological, or genotoxic based on their mechanisms. The incidence and severity of these toxicities generally increase with the drug's concentration in the body and exposure time.Pharmacological toxicity is evident when the therapeutic effects of drugs overshoot into adverse reactions in a predictable, dose-dependent manner. Central nervous system (CNS) depression from barbiturates is a classic example, with effects escalating from...
01:36Types of Toxins
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
01:26Toxic Reactions: Overview
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
01:27The Periodic Table and Organismal Elements
Elements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally occurring, and only a few of them are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.
Periodic Table Provides Information...
Periodic Table Provides Information...
00:57The Periodic Table and Organismal Elements
OverviewElements are the smallest units of matter that cannot be broken down further by chemical processes. There are 118 known elements, but not all of these are naturally-occurring, and fewer still are essential for life. Living matter is composed primarily of carbon, nitrogen, hydrogen, and oxygen, with smaller amounts of other elements like calcium, phosphorus, potassium, and sulfur. Other elements are also necessary for life but only in trace amounts.The Periodic Table Provides Information...
01:24Drug Toxicity: Risk factors
Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...