Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Local Anesthetics: Clinical Application as Spinal Anesthesia

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Opioid prescribing trends in pain management clinics in Taiwan: 2008-2018: A population-based retrospective study.

Medicine·2026

Same author

TAAR1-Associated Trace Amines for Cutaneous Nociceptive Blockade in Rats.

Fundamental & clinical pharmacology·2026

Same author

Eccentric Cycling Improves Cardiopulmonary Fitness, Respiratory Function, and Quality of Life in Chronic Kidney Disease: A Randomized Controlled Trial.

Annals of rehabilitation medicine·2026

Same author

Synephrine potentiates lidocaine-induced cutaneous analgesia via α-adrenergic receptors in male rats.

Physiological reports·2026

Same author

Intrathecal Nalbuphine and Naloxone Produce Nociceptive and Motor Block in Rats.

Current neuropharmacology·2026

Same author

The effectiveness of the AI-based RehabLung mobile rehabilitation system on cardiopulmonary function and user satisfaction in lung cancer patients undergoing thoracic surgery: a protocol for a two-arm randomized clinical trial.

Therapeutic advances in respiratory disease·2026

Search research articles

Related Experiment Video

Updated: May 30, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

Isoflurane for spinal anesthesia in the rat.

Ching-Hsia Hung¹, Chin-Chen Chu, Yu-Chung Chen

¹Institute & Department of Physical Therapy, National Cheng Kung University, Tainan, Taiwan.

Neuroscience Letters

|July 26, 2011

Summary

Isoflurane demonstrates spinal anesthetic effects similar to lidocaine in rats, blocking motor function, proprioception, and nociception. While less potent, isoflurane provides a significantly longer duration of action for spinal anesthesia.

More Related Videos

Use of a Low-flow Digital Anesthesia System for Mice and Rats

Use of a Low-flow Digital Anesthesia System for Mice and Rats

Published on: September 7, 2016

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Related Experiment Videos

Last Updated: May 30, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

Use of a Low-flow Digital Anesthesia System for Mice and Rats

Use of a Low-flow Digital Anesthesia System for Mice and Rats

Published on: September 7, 2016

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Acquisition of Resting-State Functional Magnetic Resonance Imaging Data in the Rat

Published on: August 28, 2021

Area of Science:

Anesthesiology
Neuroscience
Pharmacology

Background:

Isoflurane, a non-water soluble anesthetic, is known to block Na+ currents.
Its potential as a spinal anesthetic has not been previously investigated.

Purpose of the Study:

To evaluate the local anesthetic effect of isoflurane when administered intrathecally.
To compare the efficacy and duration of isoflurane's spinal blockade with lidocaine.

Main Methods:

Intrathecal injection of isoflurane in a rat model.
Evaluation of spinal anesthetic effects on motor function, proprioception, and nociception.
Lidocaine used as a control for comparison.

Main Results:

Isoflurane produced dose-related spinal blockades affecting motor function, proprioception, and nociception, similar to lidocaine.
Isoflurane exhibited lower potency (27.6 [25.4-30.0]) compared to lidocaine (1.0 [0.9-1.1]) (P<0.001).
Isoflurane resulted in a significantly longer duration of spinal blockade than lidocaine at equianesthetic doses (P<0.001).

Conclusions:

Isoflurane possesses spinal anesthetic properties.
Compared to lidocaine, isoflurane offers a less potent but substantially longer-lasting spinal blockade.