Related Experiment Video
Updated: May 30, 2026
A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
Published on: July 5, 2024
Prospective, randomized comparison between raloxifene and clomiphene citrate for ovulation induction in polycystic
Ernesto de Paula Guedes Neto1, Ricardo Francalacci Savaris, Helena von Eye Corleta
1Postgraduate Program in Medicine, Ciências Cirúrgicas, Universidade Federal do Rio Grande do Sul, Rio Grande do Sul, Brazil.
Objective:
To compare the ovulation rate between raloxifene and clomiphene citrate (CC) in patients with polycystic ovary syndrome (PCOS).
Design:
Double-blind, randomized, superiority clinical trial.
Setting:
Tertiary university hospital.
Patient(S):
Women with ovulatory dysfunction and PCOS based on the Rotterdam criteria.
Intervention(S):
One of two oral treatments: 5 days of 100 mg/day of CC or R.
Main Outcome Measure(S):
Ovulation, based on follicle collapse on serial ultrasound and midsecretory serum progesterone concentration (≥3 ng/dL).
Result(S):
The women with PCOS (n = 82) were randomized to receive CC (n = 40) or raloxifene (n = 42). From these, 68 patients finished the trial according to the protocol (CC: n = 37; raloxifene: n = 31). There were no statistically significant differences between the groups in ovulation rates per an intention-to-treat analysis based on ultrasound alone (CC: 21 of 40 vs. raloxifene: 17 of 42) or on progesterone levels (CC: 16 of 40 vs. raloxifene: 11 of 42). No serious adverse events were observed in either group.
Conclusion(S):
No statistically significant difference in ovulation was observed between raloxifene and clomiphene citrate in patients with PCOS with ovulatory dysfunction.
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