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Single-channel Analysis and Calcium Imaging in the Podocytes of the Freshly Isolated Glomeruli
Published on: June 27, 2015
Angiotensin II, a missing node in new pathogenic glomerulotubular feedback loop
Jian-Dong Zhang1, Bi-Cheng Liu
1Institute of Nephrology, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Abstract:
Recently, a pathogenic glomerulotubular feedback loop was proposed to be a mechanism involving in the transition from acute kidney diseases to chronic status, with highlighting immune cells as a center of this loop. Several important limitations largely reduce its applicable content. Here we amended this proposal by introducing Ang II as a missing node into the paradigm. We believe that better understanding key questions such as interactions between Ang II and immune cells may foster new promising therapeutic options in the prevention of acute-to-chronic transition.
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