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Published on: October 17, 2018
Vitamin E differentially affects short term exercise induced changes in oxidative stress, lipids, and inflammatory
M Garelnabi1, E Veledar, J White-Welkley
1Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, MA, USA.
Summary
This study found that while exercise improves cardiovascular health markers, vitamin E supplementation did not enhance these benefits. Exercise alone showed positive trends in lipids and inflammation, with some correlations observed between fitness levels and these markers.
Area of Science:
- Cardiovascular Health
- Exercise Physiology
- Nutritional Science
Background:
- Physical activity is a known factor in preventing cardiovascular diseases.
- The role of vitamin E supplementation in modulating exercise benefits requires investigation.
Purpose of the Study:
- To determine if vitamin E supplementation affects the cardiovascular benefits derived from exercise.
- To explore the impact of vitamin E on exercise-induced changes in lipids, oxidative stress, and inflammation.
Main Methods:
- 455 healthy adults participated in a 2-month aerobic exercise program.
- Participants were randomized to receive vitamin E (800 IU) or a placebo.
- Blood samples were collected bi-weekly to measure lipids, oxidative stress, and inflammation markers; VO2 and treadmill duration were also assessed.
Main Results:
- No significant changes were observed in lipid levels or markers of oxidative stress and inflammation between groups.
- Both exercise groups showed favorable trends in lipids and some oxidative stress/inflammatory markers.
- Significant correlations were found between VO2 max, lipid reduction, and inflammatory markers (MCP-1, hs-CRP) in the placebo and vitamin E groups.
Conclusions:
- Exercise training may induce oxidative stress, which could contribute to favorable lipid reduction and improvements in oxidative stress and inflammation markers.
- Vitamin E supplementation did not appear to provide additional benefits regarding oxidative stress and inflammation in the context of this exercise program.
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