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Synthesis of N-(phosphonoacetyl)-dipeptide derivatives and evaluation of their antihypertensive activity
G Osapay1, P Körmöczy, I Szilágyi
1Research Institute of Chinoin Pharmaceutical and Chemical Works, L Eötvös University, Budapest, Hungary.
Die Pharmazie
|September 1, 1990
Abstract:
A series of N-(phosphonoacetyl)-dipeptide derivatives was synthesized for pharmacological testing as antihypertensive compounds. Several of these compounds demonstrated a moderate antihypertensive effect in Wistar spontaneous hypertensive rats (SHR) with p.o. dosing. ACE inhibition by the compounds was studied using ACE from rat plasma and lung. Inhibitors containing esterified C-termini are pro-drugs and showed activity only for plasma ACE.