Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Desipramine induces cardiac beta-adrenergic sensitivity decrease in major depressed patients without relationship to

G Bertschy1, S Vandel, A Puech

  • 1Service de Psychiatrie, C.H.U. St. Jacques, Besançon, France.

Pharmacopsychiatry
|November 1, 1990
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Minimally invasive Rives-Stoppa (MIRS) technique: a technique of retromuscular repair of ventral hernias preserving the posterior rectus sheath.

Hernia : the journal of hernias and abdominal wall surgery·2025
Same author

Some Additional Data That Might Be Useful for Diastasis Recti Assessment.

Journal of abdominal wall surgery : JAWS·2024
Same author

Virtual Reality Therapy in Palliative Care: A Case Series.

Journal of palliative care·2022
Same author

Patterns of integrating palliative care into standard oncology in an early ESMO designated center: a 10-year experience.

ESMO open·2021
Same author

Exposure-safety and efficacy response relationships and population pharmacokinetics of eslicarbazepine acetate.

Acta neurologica Scandinavica·2018
Same author

Persistent Organic Pollutants in albacore tuna (Thunnus alalunga) from Reunion Island (Southwest Indian Ocean) and South Africa in relation to biological and trophic characteristics.

Environmental research·2016
Same journal

Correction: Escitalopram and Clonazepam Affect Gasotransmitter-related Enzyme (nNOS, HO-2, CBS) Gene Expression in the Rat Brain.

Pharmacopsychiatry·2026
Same journal

Correction: Non-Response to Antidepressants: Risk Factors and Therapeutic Possibilities.

Pharmacopsychiatry·2026
Same journal

Consensus Guidelines for Therapeutic Drug Monitoring in Neuropsychopharmacology: Update 2026 - Pharmacokinetic, pharmacogenetic and clinical aspects.

Pharmacopsychiatry·2026
Same journal

Therapeutic Drug Monitoring of Cannabinoids: Therapeutic Reference Ranges for Delta-9-tetrahydrocannabinol in Medical Cannabis, Nabiximols, Dronabinol and Nabilone.

Pharmacopsychiatry·2026
Same journal

A Naturalistic Study on the Cost Reduction and Efficacy of Long-acting Antipsychotics in an Early Intervention Programme for Patients with Recent-onset Psychosis.

Pharmacopsychiatry·2026
Same journal

High Clozapine Serum Levels Do Not Improve Response: An Observational Study in Patients with Schizophrenia Treated with Clozapine in a Naturalistic Setting.

Pharmacopsychiatry·2026
See all related articles

Desipramine treatment decreased cardiac beta-adrenergic receptor sensitivity in major depressed patients. This change did not correlate with clinical improvement or drug levels.

Area of Science:

  • Pharmacology
  • Psychiatry
  • Cardiology

Background:

  • Major depressive disorder (MDD) is a prevalent psychiatric condition.
  • Antidepressant medications like desipramine are commonly prescribed.
  • Cardiac autonomic function is often altered in depression.

Purpose of the Study:

  • To investigate the effect of desipramine on cardiac beta-adrenergic receptor sensitivity in patients with major depression.
  • To explore the relationship between changes in beta-adrenergic sensitivity and clinical outcomes.

Main Methods:

  • Nineteen inpatients with major depression received desipramine for three weeks.
  • Cardiac beta-adrenergic receptor sensitivity was assessed using an isoproterenol challenge test before and after treatment.
  • Measurements included the isoproterenol dose required to increase heart rate by 20 beats per minute (ID20).

Related Experiment Videos

Main Results:

  • Desipramine treatment significantly decreased cardiac beta-adrenergic sensitivity (p < 0.03).
  • The ID20 increased from 89 +/- 37 ng/kg pre-treatment to 170 +/- 135 ng/kg post-treatment.
  • A linear relationship was observed between pre-treatment sensitivity and post-treatment clinical state.
  • No correlation was found between post-treatment sensitivity and therapeutic response or desipramine plasma levels.

Conclusions:

  • Desipramine reduces cardiac beta-adrenergic receptor sensitivity in major depression.
  • This desipramine-induced change in sensitivity is not directly linked to treatment efficacy or drug concentration.