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Updated: May 30, 2026

Assessing Teratogenic Changes in a Zebrafish Model of Fetal Alcohol Exposure
Published on: March 20, 2012
Short-term effects and teratogenicity of heptanol on embryos of Xenopus laevis
Eva Olmedo1, Lidia Bardia, Jordi Domingo
1Department of Cell Biology and Pathology, Universtat de Barcelona, Campus de Bellvitge, Feixa Llarga, 08907 L'Hospitalet de Llobregat, Barcelona, Spain.
Abstract:
This study examined teratogenic and short-term effects of heptanol on Xenopus embryos. Embryos were exposed for 5h to 2.5mM heptanol at different developmental stages. Teratogenic effects were found in embryos treated from cleavage to early neurula stages. Other heptanol concentrations, shorter exposure time, and the effect of temperature were also assayed. Short-term effects of hepatanol exposure were studied during cleavage and all treated blastulae showed cell separation with delaminated blastomeres inside the blastocel. Disruption of cell adhesion in addition to the uncoupling effect could account for heptanol teratogenicity.

