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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

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[Amoxicillin-induced cholestatic hepatitis].

María Lourdes Ruiz Rebollo¹, Rocío Aller De La Fuente, Ana Macho Conesa

¹Servicio de Gastroenterología, Hospital Clínico Universitario, Valladolid, España. ruizrebollo@hotmail.com

Gastroenterologia Y Hepatologia

|July 26, 2011

Summary

Drug-induced liver injury from antibiotics is common, but amoxicillin is a rare cause. This case highlights a rare instance of cholestatic hepatitis in an elderly patient due to amoxicillin, emphasizing the need for vigilance.

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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

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Inducing Acute Liver Injury in Rats via Carbon Tetrachloride (CCl4) Exposure Through an Orogastric Tube

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Published on: April 28, 2020

Area of Science:

Hepatology
Pharmacology
Internal Medicine

Background:

Drug-induced liver injury (DILI) poses a significant clinical challenge.
Antibiotics are a frequent cause of DILI.
Amoxicillin-induced liver injury is considered uncommon.

Observation:

An 87-year-old male patient presented with symptoms of liver injury.
The patient had been prescribed amoxicillin 500 mg every 8 hours for dental disease.
Cholestatic hepatitis was diagnosed.

Findings:

The patient developed cholestatic hepatitis following amoxicillin ingestion.
This presentation is atypical for amoxicillin, which is rarely associated with liver injury.
A literature review on amoxicillin-induced liver injury was conducted.

Implications:

This case underscores the potential for amoxicillin to cause liver injury, albeit rarely.
Clinicians should maintain a high index of suspicion for DILI, even with commonly prescribed drugs.
Further research into the mechanisms of rare DILI is warranted.