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Updated: May 30, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
Published on: December 7, 2012
[Pathogen inactivation of platelets: organization consequences for platelet transfusion]
P Chavarin1, C DePutter, F Boussoulade
1Établissement français du sang Auvergne-Loire, Saint-Étienne, France. patricia.chavarin@efs.sante.fr
Pathogen reduction technologies enhance blood safety by inactivating infectious pathogens. Implementing amotosalen/HCl/UVA (Intercept™) for platelet concentrates requires practice improvements but has minimal organizational impact.
Area of Science:
- Blood safety
- Transfusion medicine
- Pathogen inactivation technologies
Context:
- Residual risks of transmitting infectious pathogens in labile blood products.
- Feasibility study and reinforced haemovigilance for amotosalen/HCl/UVA (Intercept™) technology implementation.
- Analysis of organizational consequences for platelet concentrate inventory and distribution.
Purpose:
- To assess the organizational impact of implementing pathogen inactivation technology for platelet concentrates.
- To review and improve practices in blood donation services and labile blood product preparation laboratories.
- To evaluate the routine implementation consequences on overall organization.
Summary:
- Implementation of pathogen inactivation for platelet concentrates necessitates practice reviews and improvements in blood services and laboratories.
- Routine use of amotosalen/HCl/UVA (Intercept™) technology shows minimal major organizational consequences.
- The study focused on organizational aspects, excluding economic factors.
Impact:
- Enhanced transfusion safety through pathogen reduction technologies.
- Identified areas for practice improvement in blood product handling.
- Demonstrated the feasibility of integrating new technologies with manageable organizational adjustments.
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