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Decrease in brain serotonin level and short term memory loss in mice: a preliminary study.

Sampa Banik¹, Twisha Lahiri

¹Department of Neuroendocrinology, Chittaranjan National Cancer Institute, 37 S.P. Mukherjee Road, Kolkata 700026, India.

Environmental Toxicology and Pharmacology

|July 26, 2011

Summary

Chronic benzene exposure via drinking water significantly lowers serotonin levels in the brain. This neurochemical change correlates with impaired short-term memory in mice.

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Area of Science:

Neuroscience
Toxicology
Environmental Health

Background:

Benzene exposure is primarily linked to hematotoxic and genotoxic effects.
The impact of benzene on central neurotransmitters and cognitive behavior remains unclear.

Purpose of the Study:

To investigate the effect of chronic benzene exposure on central neurotransmitters.
To determine the relationship between benzene exposure, neurotransmitter levels, and cognitive function.

Main Methods:

Mice were chronically exposed to benzene through drinking water.
Serotonin (5-hydroxytryptamine, 5-HT) levels were measured in specific brain regions.
Cognitive function was assessed using the passive avoidance test.

Main Results:

Benzene exposure significantly reduced serotonin levels in key brain regions.
Benzene-treated mice exhibited a decline in short-term memory performance.
A correlation was observed between reduced serotonin and memory impairment.

Conclusions:

Chronic benzene exposure affects central neurotransmitter systems.
Benzene-induced serotonin inhibition may contribute to cognitive deficits, specifically short-term memory loss.