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Alterations in rabbit aorta induced by types I and II pyrethroids
Cinzia Nasuti1, Franco Cantalamessa, Craig J Daly
1Department of Experimental Medicine and Public Health, University of Camerino, Via M. Scalzino 3, 62032 Camerino (MC), Italy.
Environmental Toxicology and Pharmacology
|July 26, 2011
Summary
Pyrethroid pesticides like permethrin and cypermethrin harm smooth muscle cells in rabbit aortas. Permethrin appears to cause greater oxidative stress than cypermethrin.
Area of Science:
- Cardiovascular Science
- Toxicology
- Cell Biology
Background:
- Pyrethroids are known to induce reactive oxygen species.
- Smooth muscle cell integrity in response to pyrethroids is not well-understood.
Purpose of the Study:
- To investigate the effects of permethrin and cypermethrin on rabbit aorta smooth muscle cell viability.
- To compare the cytotoxic impact of permethrin and cypermethrin on aortic tissue.
Main Methods:
- Confocal laser scanning fluorescence microscopy was used to assess cell viability in living rabbit aorta.
- A double-labeling protocol differentiated the cytotoxic effects of each pyrethroid.
Main Results:
- Pyrethroid treatment (10-100μM) significantly impaired smooth muscle cell viability.
- Permethrin demonstrated a more pronounced oxidative stress effect on the aorta wall compared to cypermethrin.
Conclusions:
- Permethrin and cypermethrin negatively affect aorta smooth muscle cell integrity.
- Permethrin exhibits a stronger potential for inducing oxidative stress in the aorta wall than cypermethrin.
