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Updated: May 30, 2026
Quantitative Determination of De Novo Fatty Acid Synthesis in Brown Adipose Tissue Using Deuterium Oxide
Published on: May 12, 2023
Application of validated method for determination of selected polychlorinated biphenyls in human adipose tissue
1Department of Inorganic and Analytical Chemistry, Poznań University of Medical Sciences, St. Grunwaldzka 6, 60-780 Poznań, Poland.
Abstract:
The validation method has been employed to determine PCBs in human female adipose tissue and in different tissue samples (brain, kidney, liver and adipose tissue) collected from five donors from the Wielkopolska region, Poland. The contents of 15 PCB congeners have been determined in the tissues (brain, kidney, liver and adipose tissue) of 5 donors aged 18-78. The highest PCB concentrations have been found in the adipose tissue, in which the total of 15 congeners occur in the amount 78-591ng/g tissue, and in the liver tissue in the amount 16-94ng/g tissue. In 16 samples of adipose tissue taken from women aged 25-36, 4 PCB congeners (PCB 105, 138, 150 and 180) have been determined. The mean content of the total of these congeners has been 41ng/g tissue. This result is lower than the concentration of analogous PCB in the tissues collected from women from the other European countries, which well correlates with the low content of PCB in the food produced in Poland.
