Resveratrol ameliorates carbon tetrachloride-induced acute liver injury in mice

Present investigation aimed to evaluate the hepatoprotective potential of resveratrol (30mg/kg, po) in mice following two different routes (po and sc) of exposure to carbon tetrachloride (CCl(4), 1.0ml/kg). Administration of CCl(4) caused significant increase in the release of transaminases, alkaline phosphatase, lactate dehydrogenase, γ-glutamyl transpeptidase, creatinine kinase, total bilirubin, urea and uric acid in serum. Significantly enhanced hepatic lipid peroxidation and oxidized glutathione with marked depletion in reduced glutathione were observed after CCl(4) intoxication. It was also found that CCl(4) administration caused severe alterations in liver histology. Hepatic injury was more severe in those animals who received CCl(4) by oral route than those who exposed to CCl(4) subcutaneously. Resveratrol treatment was able to mitigate hepatic damage induced by acute intoxication of CCl(4) and showed pronounced curative effect against lipid peroxidation and deviated serum enzymatic variables as well as maintained glutathione status toward control. Treatment of resveratrol lessened CCl(4) induced damage in liver. The results of the present study suggest that resveratrol has potential to exert curative effects against liver injury.