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Genome-wide association study of the child behavior checklist dysregulation profile

Eric Mick1, James McGough, Sandra Loo

  • 1University of Massachusetts Medical School, Worcester, MA 01655, USA. eric.mick@umassmed.edu

Journal of the American Academy of Child and Adolescent Psychiatry
|July 26, 2011
PubMed

Insights

This study investigated genetic factors influencing emotional dysregulation in children with attention-deficit/hyperactivity disorder (ADHD) using a genome-wide association study of the Child Behavior Checklist-DP. No significant associations were found, but several candidate genes suggest links to memory and learning pathways.

Area of Science:

  • Child and Adolescent Psychiatry
  • Behavioral Genetics
  • Neurodevelopmental Disorders

Background:

  • Emotional dysregulation is a key concern in childhood psychopathology.
  • The Child Behavior Checklist-DP (CBCL-DP) measures a heritable trait linked to later mood and behavioral problems.
  • Attention-deficit/hyperactivity disorder (ADHD) is associated with increased risk for emotional dysregulation.

Purpose of the Study:

  • To conduct a genome-wide association study (GWAS) of the CBCL-DP in children diagnosed with ADHD.
  • To identify genetic variants associated with emotional dysregulation traits in this population.

Main Methods:

  • Genome-wide association analyses were performed on 341 ADHD offspring from 339 trio families.
  • Genotyping utilized Illumina Human1M or Human1M-Duo BeadChip platforms.
  • Data analysis employed the MQFAM multivariate extension of PLINK.

Main Results:

  • No genome-wide statistically significant associations were detected for the CBCL-DP.
  • Several candidate genes (TMEM132D, LRRC7, SEMA3A, ALK, STIP1) showed suggestive associations (p < 5E-05).

Conclusions:

  • Suggestive evidence links developmentally expressed genes involved in hippocampal memory and learning to the CBCL-DP.
  • Further research is needed to confirm these candidate genes and their role in emotional dysregulation.
Abstract

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