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Differences in heart stroke volume between Han and Korean-Chinese nationalities and correlative factors
Yangxing Pan1, Baoshen Qi, Xiaomei Zhou
1Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing.
Insights
Korean-Chinese individuals exhibit lower stroke volume (SV) and stroke volume index (SI) compared to Han individuals, linked to higher systemic vascular resistance (SVR) and heart rate (HR). These findings highlight ethnic differences in cardiovascular physiology.
Area of Science:
- Cardiovascular Physiology
- Ethnic Health Disparities
- Biomedical Research
Background:
- Understanding ethnic variations in cardiovascular function is crucial for personalized medicine.
- Stroke volume (SV) and stroke volume index (SI) are key indicators of cardiac performance.
- Previous research has not extensively compared these parameters between Han and Korean-Chinese populations.
Purpose of the Study:
- To compare stroke volume (SV) and stroke volume index (SI) between Han and Korean-Chinese ethnic groups.
- To identify risk factors correlated with observed differences in SV and SI.
- To investigate the physiological underpinnings of ethnic variations in cardiac output.
Main Methods:
- A cross-sectional study involving 1,647 Han and 876 Korean-Chinese individuals aged 10-80 years.
- Measurement of key hemodynamic parameters including SV, SI, cardiac output, heart rate (HR), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), and blood pressure.
- Statistical analyses including covariance and multiple regression to identify significant differences and correlated factors.
Main Results:
- Korean-Chinese individuals demonstrated significantly lower SV and SI compared to Han individuals of similar sex and age (P<0.001), even after adjusting for sex, age, and BMI.
- Multiple regression analysis identified SVR, SVRI, HR, and various blood pressure measures as significant correlates of SV and SI differences between the two ethnic groups.
- Higher SVR, HR, and blood pressure in the Korean-Chinese cohort were associated with their lower SV and SI.
Conclusions:
- Ethnic differences in SV and SI exist between Han and Korean-Chinese populations.
- Elevated SVR, HR, and blood pressure in Korean-Chinese individuals contribute to their lower SV and SI.
- These findings underscore the importance of considering ethnicity in cardiovascular health assessments and interventions.
Objective:
To compare the differences in stroke volume (SV) and stroke volume index (SI) between Han and Korean-Chinese and to investigate the correlated risk factors.
Methods:
A total of 1 647 Han and 876 Korean-Chinese aged 10-80 years were investigated. SV, SI, cardiac output, cardiac output index, heart rate (HR), systemic vascular resistance (SVR), systemic vascular resistance index (SVRI), and blood pressure were measured.
Results:
SV/SI values in Korean-Chinese were lower than those in the Han of the same sex and age. Covariance analysis showed that, apart from the effect of sex, age and body mass index (BMI), the differences in SV and SI between the two cohorts were still significant (P<0.001). Multiple regression analysis revealed that the SV difference between the two ethnicities was affected (in descending order from a strong to weak correlation) by SVR, SVRI, HR, diastolic blood pressure, mean arterial pressure, BMI, and systolic blood pressure, while the SI difference was affected by SVR, SVRI, HR, mean arterial pressure, diastolic and systolic blood pressure, and BMI.
Conclusion:
The Fact that SV and SI in Korean-Chinese are lower than those in Han is related with higher SVR, HR and blood pressure in the Korean-Chinese.
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