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Baseline severity but not gender modulates quantified Crataegus extract effects in early heart failure--a pooled

Thomas Eggeling1, Vera Regitz-Zagrosek, Andrea Zimmermann

  • 1Kardiologie Köln, Gemeinschaftspraxis Kardiologie, Köln, Germany.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|July 26, 2011
PubMed

Insights

Quantified Crataegus extract improved exercise capacity and symptoms in early chronic heart failure (CHF). Benefits were more pronounced with greater baseline severity, with comparable effects in men and women when baseline differences were considered.

Area of Science:

  • Cardiology
  • Pharmacology
  • Herbal Medicine

Background:

  • Chronic heart failure (CHF) is a complex condition affecting millions worldwide.
  • Quantified Crataegus extract is a widely studied herbal remedy for cardiovascular conditions.
  • Previous studies have suggested its efficacy in managing CHF symptoms and improving physiological parameters.

Purpose of the Study:

  • To evaluate the impact of baseline severity and gender on treatment outcomes in early CHF patients receiving quantified Crataegus extract.
  • To explore the associations between objective physiological endpoints and patient-reported symptoms.
  • To compare pooled analysis results with a long-term cohort study.

Main Methods:

  • A pooled analysis of data from 687 individual patients across ten studies.
  • Patients received either quantified Crataegus extract or placebo.
  • Treatment effects on maximal workload (MWL), left ventricular ejection fraction (LVEF), and pressure-heart rate product increase (PHRPI) were analyzed.
  • Symptom changes were assessed and related to physiological improvements.

Main Results:

  • Active treatment significantly improved MWL, LVEF, and PHRPI compared to placebo.
  • Improvements in MWL and PHRPI were greater in patients with higher baseline severity.
  • Symptom improvements (exercise tolerance, dyspnea, fatigue) were more pronounced in those with more severe baseline symptoms.
  • Gender differences in treatment effects were attributable to baseline variations.

Conclusions:

  • Crataegus extract demonstrates efficacy in improving physiological outcomes and symptoms in early CHF.
  • Treatment benefits are modulated by baseline disease severity.
  • When baseline differences are accounted for, quantified Crataegus extract offers comparable benefits to both male and female patients with impaired exercise tolerance.
Abstract

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