Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diurnal variation of the distance between cranium and the third lumbar vertebra and its implications for craniospinal irradiation.

Physics and imaging in radiation oncology·2025
Same author

Dosimetric consequences of adapting the craniocaudal isocenter distance to daily patient position in craniospinal irradiation using volumetric modulated arc therapy.

Journal of applied clinical medical physics·2024
Same author

Surface-guided radiotherapy systems in locoregional deep inspiration breath hold radiotherapy for breast cancer - a multicenter study on the setup accuracy.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology·2024
Same author

Dosimetric effect of rotational setup errors in volumetric modulated arc therapy and field-in-field treatment of left-sided breast cancer.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2024
Same author

Patient setup accuracy in DIBH radiotherapy of breast cancer with lymph node inclusion using surface tracking and image guidance.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2022
Same author

Comparison of three differently shaped ROIs in free breathing breast radiotherapy setup using surface guidance with AlignRT<sup>®</sup>.

Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology·2021

Related Experiment Video

Updated: May 30, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Parkinson's disease: interhemispheric textural differences in MR images.

Minna Sikiö1, Kirsi K Holli, Lara C V Harrison

  • 1Medical Imaging Center, Tampere University Hospital, Finland. minna.sikio@iki.fi

Academic Radiology
|July 26, 2011
PubMed
Summary

Texture analysis of MRI scans reveals interhemispheric differences in early Parkinson's disease (PD) patients, particularly in the basilar pons and midbrain. This imaging technique aids in detecting subtle textural changes for improved diagnosis.

More Related Videos

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Related Experiment Videos

Last Updated: May 30, 2026

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data
14:27

Identification of Disease-related Spatial Covariance Patterns using Neuroimaging Data

Published on: June 26, 2013

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI&#8212;Application in Premanifest Huntington's Disease
09:06

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease

Published on: June 9, 2018

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

  • Neuroimaging
  • Radiology
  • Medical Diagnostics

Background:

  • Early diagnosis of Parkinson's disease (PD) is crucial for treatment and prognosis.
  • Currently, no definitive diagnostic test exists for PD.
  • Subtle hemispheric changes in early parkinsonism warrant investigation.

Purpose of the Study:

  • To evaluate texture analysis (TA) of MRI for detecting interhemispheric textural changes in early PD.
  • To identify functional TA parameters for assessing textural alterations.
  • To explore the role of TA in differentiating between brain hemispheres in patients with parkinsonism.

Main Methods:

  • Fifty-one PD patients and 20 healthy controls underwent 3-T MRI.
  • Co-occurrence matrix-based TA was applied to various brain structures.
  • Statistical analysis used the Mann-Whitney U test.

Main Results:

  • Significant interhemispheric textural differences were observed in PD patients, notably in the basilar pons and midbrain.
  • Four discriminant TA parameters were identified: correlation, contrast, difference variance, and sum variance.
  • These parameters also detected differences in the dentate nucleus, globus pallidus, and corona radiata.

Conclusions:

  • Co-occurrence matrix-based TA can identify interhemispheric differences in MRI of PD patients.
  • The identified areas align with known PD pathophysiology and neuroanatomy.
  • TA shows promise as a tool for early PD detection and characterization.