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[Premedication with triazolam].

H Smonig1, K H Glaser, H Höfler

  • 1Institut für Anästhesiologie des LKH Graz.

Anasthesie, Intensivtherapie, Notfallmedizin
|January 1, 1990
PubMed
Summary

Triazolam and flunitrazepam are comparable oral premedicants for gynecological surgery. Triazolam offers antidepressant effects, while flunitrazepam may increase asthenic effects, with both effectively reducing anxiety.

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Oral premedication is crucial for managing preoperative anxiety in surgical patients.
  • Benzodiazepines are commonly used for their anxiolytic and sedative properties.

Purpose of the Study:

  • To compare the efficacy and side effect profiles of triazolam and flunitrazepam as oral premedicants.
  • To evaluate their impact on anxiety, mood, sedation, and amnesia in patients undergoing gynecological surgery.

Main Methods:

  • A randomized trial involving 65 female patients scheduled for gynecological surgery.
  • Patients received either 0.5 mg triazolam or 2 mg flunitrazepam orally 90 minutes preoperatively.
  • Anxiety, mood, sedation, amnesia, and vital signs were assessed.

Main Results:

  • Both triazolam and flunitrazepam demonstrated significant anxiolytic effects, with efficacy dependent on initial anxiety levels.
  • Triazolam showed antidepressant effects and decreased asthenic effects, whereas flunitrazepam tended to increase depression and asthenic effects.
  • No significant differences were observed in sedation or amnestic effects; vital signs showed comparable changes except for heart rate, which increased with triazolam and decreased with flunitrazepam.

Conclusions:

  • Triazolam is a suitable alternative to flunitrazepam for oral premedication in short surgical procedures, especially when rapid postoperative recovery is desired.
  • The choice between triazolam and flunitrazepam may depend on the desired effect on mood and potential impact on heart rate.

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