Moxifloxacin prophylaxis for chemoembolization or embolization in patients with previous biliary interventions: a...

Area of Science:

• Hepatobiliary Malignancy
• Interventional Radiology
• Infectious Disease

Background:

• Abscess formation is a significant risk following intraarterial therapy for hepatic malignancy, particularly in patients with colonized bile ducts.
• Current prevention strategies often involve a combination of antibiotic prophylaxis and bowel preparation.
• The necessity of bowel preparation alongside antibiotic prophylaxis warrants investigation.

Purpose of the Study:

• To evaluate the efficacy of moxifloxacin prophylaxis alone in preventing hepatic abscesses after intraarterial therapy.
• To determine if bowel preparation can be omitted when using moxifloxacin for prophylaxis.

Main Methods:

• A retrospective review of patients undergoing intraarterial therapy for hepatic malignancy.
• Patients received moxifloxacin prophylaxis without bowel preparation.
• Outcomes including abscess formation were monitored.

Main Results:

• Ten patients underwent a total of 25 procedures.
• The median follow-up duration was 250 days.
• No instances of hepatic abscess formation were observed in the study cohort.

Conclusions:

• Moxifloxacin prophylaxis alone appears to be effective in preventing hepatic abscesses.
• The findings suggest that bowel preparation may not be necessary when using moxifloxacin for prophylaxis in this patient population.
• This simplified approach could improve patient tolerance and reduce procedural complexity.