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Related Experiment Video

Updated: May 30, 2026

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Quantitating Iron Transport Across the Mouse Placenta In Vivo Using Nonradioactive Iron Isotopes

Published on: May 10, 2022

Iron and intestinal immunity.

Bobby J Cherayil¹, Shiri Ellenbogen, Nandakumar N Shanmugam

¹Mucosal Immunology Laboratory, MassGeneral Hospital for Children, Charlestown, Massachusetts, USA. cherayil@helix.mgh.harvard.edu

Current Opinion in Gastroenterology

|July 26, 2011

Summary

Recent research highlights how iron metabolism influences gastrointestinal inflammation. Hepcidin, a key iron regulator, mediates this interaction, offering new therapeutic targets for inflammatory bowel disease.

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Area of Science:

Gastroenterology
Immunology
Metabolic Research

Background:

Iron metabolism and inflammation are intricately linked in the gastrointestinal tract.
Understanding these interactions is crucial for deciphering disease pathogenesis.

Purpose of the Study:

To review recent advances in understanding the molecular basis of iron-inflammatory responses in the GI tract.
To explore the role of hepcidin in mediating these interactions.

Main Methods:

Review of current literature on iron metabolism, inflammation, and the GI tract.
Analysis of the role of hepcidin as a mediator between iron homeostasis and inflammation.

Main Results:

Iron impacts both microbial enteropathogens and the intestinal microbiota.
Hepcidin emerges as a key regulator, linking iron homeostasis and inflammation.
Hepcidin modulation shows promise in animal models of inflammatory bowel disease.

Conclusions:

New insights into iron metabolism illuminate GI inflammatory disease pathogenesis.
Emerging information suggests novel therapeutic strategies targeting iron metabolism.