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Revisiting the Sham: Is It all Smoke and Mirrors?
Brandon Horn1, Judith Balk, Jeffrey I Gold
1Eastern Center for Complementary Medicine, PC, Los Angeles, California, USA.
Abstract:
The misuse of sham controls in examining the efficacy or effectiveness of Complementary and Alternative Medicine has created numerous problems. The theoretical justification for incorporating a sham is questionable. The sham does not improve our control of bias and leads to relativistic data that, in most instances, has no appropriate interpretation with regards to treatment efficacy. Even the concept of a sham or placebo control in an efficacy trial is inherently paradoxical. Therefore, it is prudent to re-examine how we view sham controls in the context of medical research. Extreme caution should be used in giving weight to any sham-controlled study claiming to establish efficacy or safety.
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