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Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis
08:59

Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis

Published on: July 16, 2021

Amyotrophic lateral sclerosis: one or multiple causes?

Aline Furtado Bastos1, Marco Orsini, Dionis Machado

  • 1Serra dos Órgãos University, Teresópolis, Rio de Janeiro;

Neurology International
|July 26, 2011
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) etiology remains unknown, with no consensus on causes. Research suggests potential links to heavy metals, environmental factors, genetics, viruses, and physical activity.

Keywords:
amyotrophic lateral sclerosisetiologyhypothesismotor neuron diseaseneuromuscular Diseasesreview.

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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
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ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is the most common adult motor neuron disease.
  • It involves progressive upper and lower motor neuron compromise.
  • Most ALS cases are sporadic with unknown specific causes.

Purpose of the Study:

  • To review and present various hypotheses on the etiology of ALS.
  • To consolidate current understanding of ALS causes.

Main Methods:

  • Literature search conducted in Bireme, Scielo, and Pubmed databases.
  • Search covered the period from 1987 to 2011.
  • Keywords included "Amyotrophic lateral sclerosis," "motor neuron disease," "etiology," "causes," and "epidemiology" in English, Portuguese, and Spanish.

Main Results:

  • No definitive consensus exists regarding the etiology of ALS.
  • Evidence suggests potential contributing factors including heavy metal intoxication, environmental and occupational exposures, genetic mutations (e.g., superoxide dismutase 1), viral infections, and vigorous physical activity.

Conclusions:

  • The exact causes of ALS are still debated and not fully understood.
  • Further research into these potential etiologies is crucial.
  • Understanding ALS causes is vital for patient management, prevention, and improving quality of life.