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Updated: May 30, 2026

Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
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Single-cell electrical lysis of erythrocytes detects deficiencies in the cytoskeletal protein network

Ning Bao1, Gayani C Kodippili, Katie M Giger

  • 1Department of Chemical Engineering, School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, Virginia 24061, USA.

Lab on a Chip
|July 26, 2011
PubMed

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Studying the Cytoskeleton01:17

Studying the Cytoskeleton

The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...