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Updated: May 30, 2026

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Published on: June 11, 2012
Renal cocktail: too hard for a diabetic
Ankur Gupta1, Mohan Biyani, Susan J Robertson
1Department of Nephrology, The Ottawa Hospital (University of Ottawa), Riverside Campus 1967 prom. Riverside Drive, Ottawa, ON, K1H 7W9, Canada. parthankur@yahoo.com
A diabetic woman developed rapidly progressive glomerulonephritis, a rare lupus nephritis complication. Treatment led to cytomegalovirus colitis and deep vein thrombosis, highlighting complex disease and therapy effects.
Area of Science:
- Nephrology
- Immunology
- Internal Medicine
Background:
- A 67-year-old diabetic woman presented with fatigue and declining renal function.
- Initial investigations revealed proteinuria, active urine sediment, and p-ANCA positivity.
Observation:
- A diagnosis of rapidly progressive glomerulonephritis was established.
- Renal biopsy confirmed class V lupus nephritis with superimposed ANCA-associated crescentic glomerulonephritis.
Findings:
- The patient was treated with corticosteroids and cyclophosphamide.
- Two months post-treatment, she developed cytomegalovirus colitis and deep vein thrombosis.
Implications:
- This case illustrates a complex renal pathology involving dual glomerulonephritis types.
- It highlights potential severe complications arising from both the disease and its immunosuppressive treatment.
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